Neurosarcoidosis: a clinical dilemma.

A pragmatic approach to diagnosing and treating neurosarcoidosis in the 21st century.

PURPOSE OF REVIEW Neurosarcoidosis may be a serious complication of sarcoidosis. As the presentation of neurosarcoidosis is manifold, solitary nervous system sarcoidosis without systemic activity remains a difficult diagnosis. Appropriate treatment may be a dilemma. RECENT FINDINGS Most neurosarcoidosis patients present with neurological symptoms as the first manifestation. Whole-body fluorod...

Pseudotumor cerebri secondary to dural sinus thrombosis in neurosarcoidosis.

Pseudotumor cerebri as a presenting manifestation of neurosarcoidosis is rare. This case reported herein had pseudotumor cerebri secondary to dural sinus thrombosis as a presenting feature of neurosarcoidosis without known systemic sarcoidosis. Proper systemic steroid therapy resulted in ocular and systemic recovery. Neurosarcoidosis should be considered in the differential diagnosis of pseudot...

Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients

Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10(-8), odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We va...

Progressive meningoencephalitis due to neurosarcoidosis.

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis

BACKGROUND Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years. METHODS We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases...